SCH-23390 maleate

Research use only, not for human use.

SCH-23390 maleate is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).

SCH-23390 maleate is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).(In Vitro):SCH-23390 maleate is a potent and high-efficacy agonist of the human 5-HT2C receptor (Ki = 9.3 nM). SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 (1?μM) reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells.(In Vivo):SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions. SCH-23390(0.3 mg/kg i.p) is a very short-acting compound with an elimination half-life of around 25 min in the rat.

R-(+)-SCH-23390 maleate

Cell Cycle/DNA Damage

Potassium Channel

HCV

——

——

87134-87-0

403.9

C21H22ClNO5

>98% (HPLC)

——

OC(=O)\C=C/C(O)=O.CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years